Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.4K
Skin Cancer01:30

Skin Cancer

4.8K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.8K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.0K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.0K
Allergic Reactions02:06

Allergic Reactions

29.1K
Overview
29.1K
Papillary Dermis01:11

Papillary Dermis

4.0K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
4.0K
Cancer Vaccines01:30

Cancer Vaccines

544
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
544

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generative modeling for RNA splicing prediction and design.

eLife·2026
Same author

Feasibility, Acceptability, and Exploratory Efficacy of Implementing an Intervention for Preventing Postpartum Depression in Antepartum Hospitalized Patients With High-Risk Pregnancy Complications: A Mixed-Methods Experimental Study.

Women's health issues : official publication of the Jacobs Institute of Women's Health·2026
Same author

A high-penetrance intergenic variant at 9p21 confers melanoma susceptibility.

Research square·2026
Same author

Mechanistic understanding of a bifunctional carbonate additive for enhanced performance in lithium-sulfur battery.

Energy storage materials·2026
Same author

Detection of a sequence feature for recursive splicing.

bioRxiv : the preprint server for biology·2026
Same author

Clinical Characteristics of Emergency Visits Related to Recreational Psychedelic Use.

Community mental health journal·2026

Related Experiment Video

Updated: Oct 3, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.6K

Acantholytic Dyskeratosis Post-COVID Vaccination.

Kevin Yang1, Lisa Prussick2, Rebecca Hartman3,4

  • 1Tufts University School of Medicine, Boston, MA.

The American Journal of Dermatopathology
|February 16, 2022
PubMed
Summary
This summary is machine-generated.

A rare skin reaction, acantholytic dyskeratosis, occurred after the Moderna COVID vaccine. This condition mimicked Grover disease, possibly triggered by the vaccine in a patient with a history of the condition.

More Related Videos

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.1K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.1K

Related Experiment Videos

Last Updated: Oct 3, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.6K
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.1K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.1K

Area of Science:

  • Dermatology
  • Vaccinology
  • Pathology

Background:

  • Cutaneous side effects of COVID-19 vaccines are being increasingly documented.
  • Acantholytic dyskeratosis is a rare histopathological finding.
  • Grover disease (transient acantholytic dermatosis) is a benign skin condition.

Observation:

  • An eruptive, erythematous, vesiculopapular rash developed post-Moderna COVID-19 vaccination.
  • The patient had a prior history of Grover disease, which was in remission.
  • Histopathology revealed patchy suprabasal acantholysis with dyskeratotic keratinocytes.

Findings:

  • Histopathological findings mimicked Grover disease.
  • Direct immunofluorescence was negative.
  • The rash onset was temporally associated with vaccine administration.

Implications:

  • This case highlights a rare potential cutaneous adverse event following mRNA vaccination.
  • The Moderna vaccine may trigger or unmask Grover disease in susceptible individuals.
  • Further research is needed to understand vaccine-associated dermatoses and their management.