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Recent advances in biomaterial-boosted adoptive cell therapy.

Yonger Xue1,2,3, Junyi Che4, Xuemei Ji5

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Biomaterials enhance adoptive cell therapy by improving immune cell expansion and delivery. This approach addresses challenges in manufacturing and biological barriers for better treatment of cancers and autoimmune diseases.

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Area of Science:

  • Immunology
  • Cellular Biology
  • Materials Science

Background:

  • Adoptive immunotherapies show promise for malignant, autoimmune, and infectious diseases.
  • Clinical translation is hindered by insufficient effector cell populations at disease sites post-transfer.

Purpose of the Study:

  • To review biomaterial-based strategies for enhancing adoptive cell therapy efficacy.
  • To focus on function-specific biomaterial design and discuss future prospects.

Main Methods:

  • Review of recent advancements in biomaterial applications for adoptive cell therapy.
  • Focus on how biomaterials address immune cell expansion, engineering, delivery, and navigation.

Main Results:

  • Biomaterials can be engineered to improve ex vivo immune cell expansion.
  • Biomaterials facilitate protective in situ delivery and in vivo cell navigation.
  • Function-specific biomaterial design is key to enhancing therapeutic outcomes.

Conclusions:

  • Biomaterial-based engineering platforms offer solutions to challenges in adoptive cell therapy.
  • Rational design of biomaterials is crucial for improving immune cell function and therapeutic efficacy.
  • Further research into biomaterial strategies holds significant promise for clinical translation.