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Updated: Oct 3, 2025
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Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
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Hyperbaric reactions in organic synthesis. Progress from 2006 to 2021.
Alexander Yu Rulev1, Fedor I Zubkov2
1A. E. Favorsky Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia. rulev@irioch.irk.ru.
Organic & Biomolecular Chemistry
|February 16, 2022
Summary
High-pressure organic synthesis reactions above 1 kbar are reviewed for preparative applications. This technique overcomes challenges, enabling efficient synthesis of compounds from 2006-2021.
Area of Science:
- Organic Chemistry
- Chemical Engineering
- Materials Science
Background:
- High-pressure techniques offer unique reaction pathways.
- Overcoming synthetic challenges is crucial for preparative organic synthesis.
- Literature data from 2006-2021 provides a substantial foundation.
Purpose of the Study:
- To comprehensively review published literature on reactions above 1 kbar.
- To highlight advancements in high-pressure preparative organic synthesis.
- To identify and discuss overcome obstacles in high-pressure reactions.
Main Methods:
- Literature search and synthesis of data concerning reactions above 1 kbar.
- Focus on preparative organic synthesis (initial substance > 50 mg).
- Analysis of studies published between 2006 and early 2021.
Main Results:
- Compilation of over 100 references detailing high-pressure reactions.
- Demonstration of successful overcoming of synthetic obstacles using high pressure.
- Identification of key reaction types and conditions facilitated by high pressure.
Conclusions:
- High-pressure techniques are vital for specific preparative organic synthesis challenges.
- The period 2006-2021 shows significant progress in applying pressures above 1 kbar.
- Further exploration of high-pressure synthesis is warranted for novel compound preparation.
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