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Updated: Aug 14, 2026

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Published on: March 11, 2017
Pharmacokinetic and pharmacodynamic interactions between caffeine and diazepam
Caffeine and diazepam interactions were studied in healthy adults. Combining caffeine with diazepam reduced diazepam levels by 22% but did not significantly alter most drug effects.
Area of Science:
- Pharmacology
- Neuroscience
Background:
- Caffeine is a common stimulant, while diazepam is a benzodiazepine anxiolytic.
- Understanding their combined effects is crucial for drug safety and efficacy.
Purpose of the Study:
- To investigate the pharmacokinetic and pharmacodynamic interactions between caffeine and diazepam.
- To assess the impact of coadministration on drug levels and behavioral performance.
Main Methods:
- A double-blind, Latin square design was used in six healthy young adults.
- Subjects received single doses of caffeine, diazepam, or their combination.
- Blood samples and behavioral tests were collected over 210 minutes.
Main Results:
- Coadministration reduced diazepam plasma levels by 22%.
- Caffeine caused tremors; diazepam caused sedation and cognitive impairment.
- No significant antagonism was observed, except in one cognitive task.
Conclusions:
- Caffeine and diazepam exhibit complex interactions, affecting drug levels and acute tolerance.
- Further research is needed to fully elucidate these interactions.
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