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Updated: Oct 3, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Group B Streptococcal Neonatal Meningitis.

Teresa Tavares¹, Liliana Pinho², Elva Bonifácio Andrade^1,3,4

¹Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal.

Clinical Microbiology Reviews

|February 16, 2022

Summary

Group B Streptococcus (GBS) causes neonatal meningitis, a severe infant disease with lasting neurological effects. New research is needed to understand GBS meningitis mechanisms and develop better brain protection strategies.

Keywords:

Gram-positive bacteria central nervous system infections group B Streptococcus infectious disease neonatal meningitis pathogenesis

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Last Updated: Oct 3, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization

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Published on: November 16, 2016

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Area of Science:

Neonatal infectious diseases
Neuroscience
Microbiology

Background:

Neonatal bacterial meningitis, particularly GBS meningitis, leads to high mortality and neurological disability.
Despite preventative measures, GBS meningitis incidence and morbidity remain unchanged since the 1970s.
Understanding the mechanisms of GBS-induced brain injury is crucial for developing effective treatments.

Purpose of the Study:

To provide an updated review of neonatal GBS meningitis.
To discuss epidemiology, diagnosis, management, and pathogenic mechanisms.
To explore experimental models for studying GBS meningitis.

Main Methods:

Literature review of clinical data on neonatal GBS meningitis.
Analysis of human evidence regarding disease mechanisms.
Evaluation of experimental models used in GBS meningitis research.

Main Results:

GBS is the leading cause of bacterial meningitis in infants under 90 days.
Maternal GBS colonization is the primary risk factor for neonatal invasive disease.
A significant number of survivors experience long-term neurological or neuropsychiatric sequelae.

Conclusions:

Further research into GBS meningitis pathophysiology is essential.
Development of novel therapeutic and neuroprotective strategies is urgently needed.
Experimental models require careful consideration of their relevance to human disease.