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Related Experiment Video

Updated: Jul 18, 2026

4D Imaging of Protein Aggregation in Live Cells

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Aggregation-Induced Emission-Active Biomacromolecules: Progress, Challenges, and Opportunities.

Rong Hu^1,2, Jia Wang¹, Anjun Qin¹

¹State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, AIE Institute, Center for Aggregation-Induced Emission, South China University of Technology, 510641 Guangzhou, China.

Biomacromolecules

|February 16, 2022

Summary

Aggregation-induced-emission (AIE) biomacromolecules exhibit unique properties for biomedical uses. This perspective reviews AIE biomacromolecule development, applications, and future research directions.

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Area of Science:

Biomaterials Science
Organic Chemistry
Nanotechnology

Background:

Aggregation-induced-emission (AIE) phenomena offer unique photophysical properties.
AIE-active biomacromolecules display distinct characteristics in aggregated states compared to molecular states.
These properties unlock novel possibilities for advanced biomedical applications.

Purpose of the Study:

To provide a comprehensive overview of the development of AIE-active biomacromolecules.
To highlight significant advancements in synthesis, structure-property relationships, and applications.
To discuss current challenges and future opportunities in the field.

Main Methods:

Review of synthetic strategies for AIE-active biomacromolecules.
Analysis of structure-property correlations in AIE biomaterials.
Exploration of diverse biomedical applications.

Main Results:

Significant progress has been achieved in the preparation and characterization of AIE-active biomacromolecules.
Established structure-property relationships guide the design of novel AIE biomaterials.
Demonstrated potential in various biomedical fields, including imaging and diagnostics.

Conclusions:

AIE-active biomacromolecules represent a rapidly advancing area with transformative potential.
Further research into synthesis, characterization, and application is crucial.
This field offers exciting opportunities for innovation in biomaterials and aggregate science.