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Elevated CEACAM5 Levels in Patients with Asthma.

Changyi Xu^1,2, Lijuan Du^1,2, Zhimin Zeng^1,2

¹Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

International Archives of Allergy and Immunology

|February 16, 2022

Summary

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is elevated in asthma patients. This protein may serve as a diagnostic biomarker and therapeutic target for asthma, potentially linked to eosinophilic inflammation.

Keywords:

Asthma Carcinoembryonic antigen-related cell adhesion molecule 5 Diagnosis Induced sputum Serum

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Area of Science:

Respiratory medicine
Immunology
Biomarker research

Background:

Asthma is a prevalent chronic respiratory condition.
Understanding molecular markers is crucial for diagnosis and treatment.
CEACAM5 is a cell adhesion molecule with potential roles in inflammation.

Purpose of the Study:

To investigate the expression levels of CEACAM5 in asthma patients.
To explore the correlation between CEACAM5 and clinical asthma indicators.
To assess the diagnostic potential of CEACAM5 in asthma.

Main Methods:

CEACAM5 protein levels measured via ELISA in sputum supernatant and serum.
CEACAM5 gene expression analyzed by qRT-PCR in sputum cells.
Correlations with FeNO, IgE, and IL-13 assessed.
Diagnostic value evaluated using ROC curve analysis.

Main Results:

CEACAM5 expression was significantly upregulated in sputum supernatant, cells, and serum of asthma patients.
Higher CEACAM5 levels correlated with increased FeNO, IgE, and IL-13.
CEACAM5 demonstrated good diagnostic value for asthma.
IL-4 or IL-13 stimulation upregulated CEACAM5 in bronchial epithelial cells.

Conclusions:

CEACAM5 is significantly increased in asthma patients.
CEACAM5 may play a role in eosinophilic airway inflammation.
CEACAM5 shows promise as a diagnostic biomarker and therapeutic target for asthma.