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Pulmonary vein aneurysm in a New Zealand White rabbit: a case report
Jong-Min Kim1, Chang Gok Woo2, Sa Hun Kim1
1Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, 110-799, Korea.
Background:
Pulmonary venous aneurysm (PVA) is a rare condition characterized by aneurysmal dilatation of the pulmonary vein in humans. The diagnosis is incidental usually as there are no clinical symptoms. This case report describes a histological diagnosis of PVA in a New Zealand White rabbit.
Case Presentation:
A 1.5-kg male New Zealand White rabbit was acclimatized in an animal room for 5 weeks until the experiment began. However, the rabbit was found dead, with signs of nasal hemorrhage. Necropsy revealed tracheal and pulmonary hemorrhage, and the epistaxis had a pulmonary origin. PCR and ELISA to detect antigens and antibodies pertaining to the rabbit hemorrhagic disease virus showed negative results. Multiple ballooning lesions (50-200 μm size) in the pulmonary veins were observed on histological examination, and PVA was diagnosed. Death was attributed to a spontaneous rupture of the PVA and massive hemorrhage into the lung parenchyma that extended into the trachea and nasal passages.
Conclusions:
To the author's best knowledge, this is the first report of a PVA in a rabbit.
