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[The use of urokinase in urinary catheter obstructed by clots.]

María Negueroles-García1, Jorge Panach-Navarrete1, José María Martínez-Jabaloyas1

  • 1Servicio de Urología. Hospital Clínico Universitario de Valencia. Facultat de Medicina i Odontología. Universitat de València. Valencia. España.

Archivos Espanoles De Urologia
|February 17, 2022
PubMed

Insights

Urokinase effectively cleared clots in two of three patients with obstructed urinary catheters. This therapy shows promise for coagulated catheters unresponsive to other treatments.

Area of Science:

  • Urology
  • Nephrology
  • Pharmacology

Background:

  • Urinary catheter obstruction by clots is a common clinical challenge.
  • Existing treatments for coagulated catheters may be ineffective.
  • Urokinase is a thrombolytic agent with potential applications in urinary tract interventions.

Observation:

  • Three cases of urinary catheter obstruction due to clots were reviewed.
  • Patients included metastatic breast carcinoma, renal trauma, and benign ureteric obstruction.
  • Urokinase instillation was administered to all three patients.

Findings:

  • Two of the three patients experienced adequate clot resolution after urokinase instillation.
  • One patient with benign ureteric obstruction and sepsis did not respond to urokinase.
  • Urokinase was generally well-tolerated in the treated patients.

Implications:

  • Urokinase may be a viable therapeutic option for managing coagulated urinary catheters.
  • Further investigation is warranted to determine optimal urokinase protocols for catheter clearance.
  • This approach could offer an alternative for patients with refractory catheter obstruction.
Abstract

Keywords:
Catéter urinarioHemorragiaHemorrhageSistema genitourinarioUrinary cathetersUrocinasaUrogenital systemUrokinase

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