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Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target

Shafiu A Umar Shinge1, Daifang Zhang1,2, Ahmad Ud Din3

  • 1Cardiovascular Surgery Department, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan PRC.

International Journal of Biological Sciences
|February 17, 2022
PubMed

Insights

The mechanosensitive Piezo1 channel plays a key role in atherosclerosis, a major cause of cardiovascular disease. Targeting Piezo1 offers potential new therapeutic strategies for treating this condition.

Area of Science:

  • Cardiovascular Biology
  • Mechanobiology
  • Immunology

Background:

  • Atherosclerosis is a leading cause of global mortality, driven by complex cardiovascular diseases.
  • Mechanical forces significantly influence cardiovascular health and disease pathogenesis.
  • Understanding cellular responses to mechanical stimuli is crucial for cardiovascular research.

Purpose of the Study:

  • To review the role of the mechanosensitive Piezo1 channel in atherosclerosis.
  • To highlight Piezo1's involvement in disease mechanisms and its therapeutic potential.
  • To raise awareness of Piezo1's function in cardiovascular disease.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of Piezo1's role in cellular activities relevant to atherogenesis.
  • Exploration of Piezo1's drugability and therapeutic applications.

Main Results:

  • Piezo1 acts as a sensor and transducer of mechanical forces, influencing cell proliferation, migration, apoptosis, and vascular remodeling.
  • Piezo1 is implicated in immune and inflammatory mechanisms fundamental to atherogenesis.
  • Emerging evidence links Piezo1 to various cellular processes involved in atherosclerosis.

Conclusions:

  • Piezo1 is a significant player in multiple cellular mechanisms underlying atherosclerosis.
  • Piezo1 presents as a druggable target with considerable therapeutic potential for atherosclerosis.
  • Further research into Piezo1 biology is warranted for novel cardiovascular disease treatment strategies.

Keywords:
AtherosclerosisEndothelial cellInflammationPiezo1 channelmechanomedicineshear stress

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