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Related Experiment Video

Updated: Oct 3, 2025

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Brain-Predicted Age Difference Moderates the Association Between Muscle Strength and Mobility.

Brooke A Vaughan1,2, Janet E Simon1,3, Dustin R Grooms1,2,3

  • 1Ohio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH, United States.

Frontiers in Aging Neuroscience
|February 17, 2022
PubMed
Summary

Leg strength is a stronger predictor of mobility in older adults with a greater brain-predicted age difference. This suggests brain aging influences how strength impacts mobility.

Keywords:
brain agingdynapeniaphysical functionsarcopeniaweakness

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Area of Science:

  • Gerontology
  • Neuroimaging
  • Biomedical Engineering

Background:

  • Mobility limitations affect approximately 35% of adults over 70.
  • Muscle weakness is a known contributor to mobility decline in older adults.
  • Brain-predicted age difference (BPAD) offers an index of biological brain health.

Purpose of the Study:

  • To investigate the moderating effect of brain-predicted age difference (BPAD) on the relationship between leg strength and mobility.
  • To explore how biological brain age influences the association between physical strength and functional mobility in older adults.

Main Methods:

  • Assessed isokinetic leg extensor strength and a composite mobility score (MBA) in 57 community-dwelling older adults.
  • Calculated brain-predicted age (BPA) from T1 MR images using machine learning.
  • Analyzed the moderating effect of BPAD (BPA minus chronological age) using correlation and regression.

Main Results:

  • Leg strength correlated significantly with BPAD (r = -0.317, p < 0.05) and MBA score (r = 0.541, p < 0.001).
  • BPAD significantly moderated the strength-mobility relationship, explaining 7.0% of MBA variance (△R² = 0.044, p = 0.01).
  • Leg strength was a stronger predictor of mobility in individuals with a greater BPAD.

Conclusions:

  • Brain aging influences the relationship between strength and mobility in older adults.
  • Leg strength may compensate for neural integrity decline in the context of brain aging.
  • Findings highlight the interplay between neurological and physical factors in maintaining mobility.