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Related Concept Videos

Ischemic Heart Disease: Overview01:17

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Related Experiment Video

Updated: Oct 3, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Interleukins and Ischemic Stroke.

Hua Zhu1,2, Siping Hu3, Yuntao Li1,2

  • 1Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou, China.

Frontiers in Immunology
|February 17, 2022
PubMed
Summary
This summary is machine-generated.

Interleukins (ILs) significantly impact ischemic stroke outcomes by modulating immune responses and inflammation. This review explores the diverse roles of numerous ILs in stroke pathogenesis and potential therapeutic targets.

Keywords:
cytokinesinflammationinterleukinsischemic strokeneuro-immune

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Ischemic stroke, caused by cerebral artery occlusion, is a leading cause of long-term disability globally.
  • Interleukins (ILs) are critical immune mediators with complex, often opposing, roles in the inflammatory response following ischemic stroke.

Purpose of the Study:

  • To provide a comprehensive overview of the multifaceted roles of various interleukins in the context of ischemic stroke.
  • To highlight the intricate crosstalk between different ILs and immune cells affecting stroke outcomes.

Main Methods:

  • Literature review and synthesis of existing research on interleukins in ischemic stroke.
  • Analysis of the involvement of specific interleukins (IL-1 to IL-38) in immune cell activation, differentiation, and inflammatory processes.

Main Results:

  • Interleukins exhibit bidirectional effects, influencing immune cell activation, proliferation, and differentiation, thereby modulating stroke pathology.
  • The complex interplay among different ILs and their signaling pathways significantly impacts the severity and outcome of ischemic stroke.

Conclusions:

  • Interleukins are key players in ischemic stroke, offering potential targets for therapeutic intervention.
  • Understanding the specific functions and interactions of each IL is crucial for developing effective treatments to mitigate stroke-induced disability.