Related Experiment Video

Updated: Oct 3, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.9K

Antineutrophil cytoplasmic antibody positivity and clinical implications in COVID-19

Serdar Can Güven1, Hakan Apaydın1, Bahar Özdemir1

  • 1Ministry of Health Ankara City Hospital, Clinic of Rheumatology, Ankara, 06800, Turkey.

Future Virology
|February 17, 2022
PubMed

Insights

Antineutrophil cytoplasmic antibody (ANCA) positivity in COVID-19 patients, without prior rheumatic disease, may indicate worse outcomes and higher acute phase reactant levels. Further research is needed to confirm these findings.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Rheumatology

Background:

  • COVID-19 can trigger various immune responses.
  • Antineutrophil cytoplasmic antibodies (ANCAs) are typically associated with autoimmune vasculitis.

Purpose of the Study:

  • To investigate the clinical implications of ANCA positivity in COVID-19 patients.
  • To determine if ANCA positivity correlates with disease severity or outcomes in COVID-19.

Main Methods:

  • Retrospective analysis of hospital database records.
  • Comparison of clinical, laboratory, and imaging data between ANCA-positive and ANCA-negative COVID-19 patients.

Main Results:

  • ANCAs were tested in 87 COVID-19 patients; 8 were positive.
  • ANCA-positive patients showed higher acute phase reactant levels.
  • Similar COVID-19 symptoms and pulmonary involvement were observed between groups.
  • A non-statistically significant trend towards higher mortality was noted in ANCA-positive patients.

Conclusions:

  • ANCA positivity in COVID-19 patients without prior rheumatic conditions may be associated with poorer outcomes.
  • This finding warrants further investigation into the role of ANCAs in COVID-19 pathogenesis and prognosis.

Keywords:
ANCACOVID-19antineutrophil cytoplasmic antibodymortalityoutcome

More Related Videos

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.4K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-1908:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
509
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
38
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
64
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
49
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
81
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
50