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Changes in humoral immunity, myocardial damage, trace elements, and inflammatory factor levels in children with

Peihui Liu1, Rong Zou2, Jie Zhao3

  • 1Department of Pediatrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University Shenzhen City, Guangdong Province, China.

American Journal of Translational Research
|February 17, 2022
PubMed

Insights

Children with rotavirus enteritis show decreased humoral immunity and trace elements, along with increased myocardial damage and inflammation, especially with severe dehydration. Early assessment is key for treatment.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Biochemistry

Background:

  • Rotavirus enteritis is a common cause of gastroenteritis in children.
  • Dehydration is a frequent complication of rotavirus enteritis.
  • The impact of rotavirus enteritis on humoral immunity, myocardial function, and inflammatory markers requires further investigation.

Purpose of the Study:

  • To investigate changes in humoral immunity, myocardial damage, trace elements, and inflammatory factors in children with rotavirus enteritis.
  • To assess the correlation between the severity of dehydration and these physiological markers.

Main Methods:

  • Retrospective analysis of 100 children with rotavirus enteritis (categorized by dehydration severity) and 100 controls.
  • Measurement of serum immunoglobulin levels, cardiac enzyme profiles (LDH, α-HBDH, CK, CK-MB), trace elements (zinc, magnesium, calcium), and inflammatory cytokines (IL-6, IL-8, TNF-α).
  • Comparison of marker levels between case and control groups, and among dehydration severity groups.

Main Results:

  • Children with rotavirus enteritis had lower immunoglobulin, zinc, magnesium, and calcium levels, and higher LDH, α-HBDH, CK, CK-MB, IL-6, IL-8, and TNF-α levels compared to controls.
  • Increasing dehydration severity correlated with lower immunoglobulin and trace element levels.
  • More severe dehydration was associated with elevated cardiac enzyme and inflammatory marker levels.

Conclusions:

  • Severe dehydration in children with rotavirus enteritis is linked to compromised humoral immunity, depleted trace elements, exacerbated myocardial damage, and heightened inflammatory responses.
  • These findings highlight the systemic impact of rotavirus enteritis and underscore the importance of monitoring these markers for effective clinical management.
Abstract

Keywords:
Rotavirus enteritishumoral immunityinflammatory factorsmyocardial damagetrace elements

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