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Acute Isolated Thrombocytopenia Secondary to Meloxicam Use: A Case Report

Nardine Abdelsayed1, Michael Frost1, William R Betz1

  • 1Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA.

Cureus
|February 17, 2022
PubMed

Insights

Meloxicam, a common NSAID, can cause rare drug-induced thrombocytopenia (DITP), a serious condition. Prompt diagnosis and drug cessation are crucial for managing this potentially fatal side effect.

Area of Science:

  • Pharmacology
  • Hematology
  • Internal Medicine

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like meloxicam are frequently prescribed for pain and inflammation.
  • Drug-induced thrombocytopenia (DITP) is a rare but severe adverse reaction to certain medications.

Observation:

  • A 42-year-old female developed petechiae and ecchymosis after initiating meloxicam.
  • The patient presented with a critically low platelet count of 2 K/mm³.

Findings:

  • The clinical presentation and severe thrombocytopenia were consistent with meloxicam-induced DITP.
  • Differential diagnosis included immune thrombocytopenia (ITP), highlighting the importance of medication history.

Implications:

  • Early recognition of meloxicam-associated DITP is vital to prevent life-threatening hemorrhage.
  • Discontinuation of the offending NSAID is the primary treatment for DITP.
  • This case underscores the need for vigilance regarding rare NSAID side effects.
Keywords:
bleeding disordersdrug-induced thrombocytopeniaisolated thrombocytopeniameloxicamnsaids

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