Related Experiment Video
Updated: Oct 3, 2025
19:57
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
18.7K
Implementing Single-Pill Combination Therapy for Hypertension: A Scoping Review of Key Health System Requirements in
Eleanor Bruyn1, Long Nguyen1, Aletta E Schutte1,2,3
1School of Population Health, University of New South Wales, Sydney, AU.
Global Heart
|February 17, 2022
Summary
Many low- and middle-income countries (LMICs) are adopting single-pill combination (SPC) antihypertensives. Facilitators like national guidelines and market availability are present, but inclusion on essential medicines lists (EMLs) can be improved for better hypertension control.
Area of Science:
- Cardiovascular Medicine
- Public Health Policy
- Pharmacoeconomics
Background:
- The World Health Organization (WHO) added single-pill combination (SPC) antihypertensives to its 2019 Essential Medicines List (EML) to enhance hypertension management.
- Assessing national-level facilitators is crucial for understanding the uptake of SPCs in low- and middle-income countries (LMICs).
Purpose of the Study:
- To document national-level facilitators supporting the uptake of SPC antihypertensives in the 30 most populous LMICs.
- To identify key factors influencing the adoption of SPCs for improved hypertension control in LMICs.
Main Methods:
- A hierarchical information gathering strategy was employed, including literature reviews, web searches, organizational databases, and personal communications.
- Data collected focused on the presence of SPCs on national EMLs, recommendations in national hypertension guidelines, and market availability.
Main Results:
- Eleven of 30 LMICs had all three facilitators (EML inclusion, guideline recommendation, market availability) in place.
- National hypertension guidelines recommending SPCs were present in 18 of 26 countries with guidelines. SPCs were available in most markets.
- Inclusion of SPCs on national EMLs was the least common facilitator, present in only 12 of 29 countries with an EML.
Conclusions:
- Many LMICs have made substantial progress in adopting SPC antihypertensives, with some preceding the WHO's inclusion on its EML.
- Further improvement in SPC antihypertensive uptake in LMICs is possible, particularly through increased inclusion on national EMLs.
Related Concept Videos
01:28Hypertension IV: Drug Therapy and Lifestyle Modifications
92
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
92
01:26Methods Of Healthcare Delivery System
3.6K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.6K
01:28Drug Therapy
111
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
111
01:23Hypertension V: Nursing Management
59
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
59
01:30Primary Healthcare Services
1.6K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
1.6K
01:30Heart Failure V: Medical Management
39
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
39