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Updated: Oct 3, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

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Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor

Jiehan Li1, Shuning Guo1, Zhenqiang Sun2

  • 1Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Cell and Developmental Biology
|February 17, 2022
PubMed

Insights

Noncoding RNAs (ncRNAs) drive imatinib resistance in gastrointestinal stromal tumors (GIST) by affecting key cellular processes. Understanding these ncRNA mechanisms offers new therapeutic targets for overcoming drug resistance in GIST patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastrointestinal stromal tumor (GIST) is the most common gastrointestinal mesenchymal tumor.
  • GIST serves as a model for targeted therapy due to driver mutations in KIT and PDGDRA genes.
  • Imatinib mesylate is a primary targeted therapy agent for GIST, but resistance develops in over 50% of patients within two years.

Purpose of the Study:

  • To review and summarize the mechanisms by which noncoding RNAs (ncRNAs) contribute to drug resistance in GIST.
  • To explore the clinical applications of ncRNAs in GIST chemotherapies.

Main Methods:

  • Literature review summarizing existing research on ncRNAs and GIST drug resistance.
  • Categorization of ncRNA regulatory mechanisms involved in GIST drug resistance.
  • Analysis of ncRNA roles based on ncRNA type, drug, and resistance category.

Main Results:

  • ncRNAs play pivotal roles in chemotherapy drug resistance.
  • Five main regulatory mechanisms of ncRNAs in GIST drug resistance were identified: oxidative phosphorylation, autophagy, apoptosis, drug target changes, and signaling pathways.
  • ncRNA functions in drug resistance were analyzed from two aspects and categorized by ncRNA type, drug, and resistance type.

Conclusions:

  • ncRNAs are key regulators of imatinib resistance in GIST.
  • Understanding ncRNA mechanisms provides insights into overcoming drug resistance.
  • ncRNAs hold potential as prognostic biomarkers and novel therapeutic targets for GIST.
Keywords:
GISTdrug resistanceimatinib mesylatenoncoding RNAstargeted therapies

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