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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Stem cell therapy for COVID-19 pneumonia.

Maziar Malekzadeh Kebria1,2, Peiman Brouki Milan3,4, Noshad Peyravian1,2

  • 1Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran.

Molecular Biomedicine
|February 17, 2022
PubMed
Summary

Stem cell therapy shows promise for treating post-COVID complications like ARDS. These therapies may offer a regenerative approach by modulating the immune system, unlike long-term steroid use.

Keywords:
Acute respiratory distress syndromeCOVID-19CoronavirusStem cellsTissue regeneration

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Virology

Background:

  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes widespread illness, with limited treatment options for post-COVID complications.
  • Steroid therapy, while common for COVID-19 complications, carries risks like secondary infections and is insufficient for managing fibrosis and inflammation.
  • The immune system's overreaction can cause self-damage during severe infections.

Purpose of the Study:

  • To review current trends and advancements in stem cell treatments for Acute Respiratory Distress Syndrome (ARDS) following COVID-19.
  • To explore the potential of stem cell therapy as an alternative to conventional treatments for post-COVID complications.

Main Methods:

  • Review of existing research on stem cell properties and their application in immune-related diseases.
  • Analysis of studies investigating stem cell-based therapies for ARDS, particularly in the context of COVID-19.
  • Focus on mesenchymal and hematopoietic stem cells due to their immunomodulatory capabilities.

Main Results:

  • Stem cells possess immunomodulatory properties, demonstrated in treating autoimmune diseases.
  • Stem cell therapy can prime the immune system and provide essential factors for regeneration.
  • Mesenchymal or hematopoietic stem cells are potential candidates for treating COVID-19-related ARDS.

Conclusions:

  • Stem cell-based therapy presents a viable alternative for managing severe COVID-19 complications, including ARDS.
  • The immunomodulatory and regenerative potential of stem cells offers a promising avenue for long-term recovery.
  • Further research into stem cell treatments is crucial for addressing challenging post-COVID conditions.