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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

ChikvInt: a Chikungunya virus-host protein-protein interaction database

M Kusari¹, L Dey², A Mukhopadhyay¹

¹Department of Computer Science & Engineering, University of Kalyani, Kalyani, India.

Letters in Applied Microbiology

|February 17, 2022

Abstract:

Chikungunya is a fast-mutating virus causing Chikungunya virus disease (ChikvD) with a significant load of disability-adjusted life years (DALY) around the world. The outbreak of this virus is significantly higher in the tropical countries. Several experiments have identified crucial viral-host protein-protein interactions (PPIs) between Chikungunya Virus (Chikv) and the human host. However, no standard database that catalogs this PPI information exists. Here we develop a Chikv-Human PPI database, ChikvInt, to facilitate understanding ChikvD disease pathogenesis and the progress of vaccine studies. ChikvInt consists of 109 interactions and is available at www.chikvint.com.

Keywords:

chikungunya virus chikvD chikvInt protein interaction network viral-host protein-protein interactions

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