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Relieving immunosuppression by Endo@PLT targeting anti-angiogenesis to improve the efficacy of immunotherapies

Chao Chen1, Yijie Tang2, Hao Huang1

  • 1School of Public Health, Nantong University, Nantong, Jiangsu 226019, China. xiadonglin@ntu.edu.cn.

Chemical Communications (Cambridge, England)
|February 17, 2022
PubMed

Low levels of immune infiltrates in the tumor milieu hinder the effectiveness of immunotherapy against immune-cold tumors. In the current work, a tumor-targeting drug delivery system composed of Endo-loaded platelets (Endo@PLT) was developed to relieve immunosuppression by achieving tumor vascular normalization. Endo@PLT reprogrammed the immunostimulatory phenotype, achieving excellent PD-1 immunotherapy in vivo.

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