Related Experiment Video
Updated: Oct 3, 2025
07:04
Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites
Published on: November 9, 2014
13.7K
The use of desensitizing agents during in-office bleaching might not decrease tooth bleaching sensitivity: a
The International Journal of Esthetic Dentistry
|February 17, 2022
Summary
Desensitizing agents containing potassium nitrate/sodium fluoride or nanostructured calcium phosphate did not significantly reduce tooth bleaching sensitivity. These agents were acceptable to patients but did not interfere with the color change achieved during dental bleaching.
Area of Science:
- Dentistry
- Dental Materials
- Aesthetic Dentistry
Background:
- Controversial results exist regarding desensitizing agents' effect on tooth bleaching sensitivity.
- This study investigates agents with potassium nitrate/sodium fluoride (PNF) or nanostructured calcium phosphate (N).
- In-office bleaching with 35% hydrogen peroxide (HP) was used.
Purpose of the Study:
- To evaluate tooth bleaching sensitivity, color change, and patient acceptability.
- To assess PNF and N desensitizing agents during in-office HP bleaching.
Main Methods:
- Seventy-five patients were divided into three groups: bleaching only (W), bleaching with PNF gel (WD), and bleaching with N paste (WDN).
- Sensitivity and acceptability were measured using a visual analog scale.
- Color change was evaluated over time.
Main Results:
- No significant difference in sensitivity was observed between groups, except for lower sensitivity in the WD group 24 hours after the second session.
- PNF gel and N paste did not impact the color change during bleaching.
- All desensitizing treatments were acceptable to patients.
Conclusions:
- Desensitizing agents (PNF and N) did not effectively treat tooth bleaching sensitivity.
- These agents did not interfere with the color change achieved by dental bleaching.
- Patient acceptability of the desensitizing agents was high.
Related Concept Videos
01:11Blinding
3.4K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
3.4K
01:20Desensitization and Tachyphylaxis
2.4K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.4K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
978
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
978
01:23Local Anesthetics: Common Agents and Their Applications
600
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
600
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
517
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
517