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Related Experiment Video

Updated: Oct 3, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
13:51

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Published on: November 10, 2017

15.5K

Engineered lanthanide-doped upconversion nanoparticles for biosensing and bioimaging application.

Yong Li1, Chen Chen1, Fangfang Liu2

  • 1School of Environmental and Chemical Engineering, Shanghai University, 99 Shangda Road, Shanghai, 200444, China.

Mikrochimica Acta
|February 17, 2022
PubMed
Summary
This summary is machine-generated.

Upconversion nanoparticles (UCNPs) offer advanced bioimaging and biosensing capabilities due to their unique luminescence properties. This review highlights UCNP synthesis, surface modification, and biomedical applications, addressing current challenges for future development.

Keywords:
BioimagingBiosensingLanthanide-doped upconversionLuminescence

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Area of Science:

  • Nanomaterials Science
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Accurate detection of intracellular ions and biomolecules is crucial for biomedical analysis but faces challenges in sensitivity and specificity.
  • Upconversion nanoparticles (UCNPs) exhibit unique anti-Stokes luminescence properties, including sharp emission bands and photostability, making them suitable for biological applications.
  • Near-infrared (NIR) excitation of UCNPs offers deeper tissue penetration and reduced autofluorescence interference compared to traditional optical methods.

Purpose of the Study:

  • To review recent advancements in the synthesis and biomedical applications of lanthanide-doped UCNPs.
  • To explore the application of UCNPs in bioimaging and biosensing, focusing on intracellular monitoring.
  • To discuss the challenges and future perspectives for UCNPs in materials science and biomedical fields.

Main Methods:

  • Discussion of various upconversion luminescence mechanisms.
  • Comparison of four common UCNP synthesis methods, including their advantages and disadvantages.
  • Overview of surface modification techniques for UCNPs to enhance their applicability in biochemistry.

Main Results:

  • Lanthanide-doped UCNPs provide a versatile platform for bioapplications, including biosensing and bioimaging, due to tunable properties.
  • UCNPs enable multicolor imaging, multimodal imaging, and sensitive detection of intracellular ions and biomolecules.
  • NIR excitation minimizes photodamage and autofluorescence, improving signal-to-noise ratio in biological samples.

Conclusions:

  • UCNPs are promising nanomaterials for advanced bioimaging and biosensing applications.
  • Further research is needed to improve UCNP quantum yield for enhanced imaging contrast.
  • Thorough evaluation of the biosafety of lanthanide-doped UCNPs is essential for clinical translation.