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An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices

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A New In Vitro Blood Hyperviscosity Model.

A V Sidekhmenova¹, O I Aliev², N S Domnina³

¹Laboratory of Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. sidehmenova@yandex.ru.

Bulletin of Experimental Biology and Medicine

|February 17, 2022

Summary

Rat blood stored for three days at 4°C with citrate-phosphate-glucose additive solution reliably models blood hyperviscosity. A novel compound improved hemorheological properties, demonstrating the model

Keywords:

O-(3-(3,5-di-tertbutyl-4-hydroxyphenyl)propanoyl)-(1→6)-α-D-glucan blood hyperviscosity model blood storage blood viscosity

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Area of Science:

Biomedical Engineering
Hematology
Pharmacology

Background:

Blood rheology is crucial for physiological function.
Standard blood storage can alter hemorheological properties.
Developing reliable models for studying blood viscosity changes is essential.

Purpose of the Study:

To establish a reproducible model of blood hyperviscosity using stored rat blood.
To evaluate the hemorheological effects of a novel hybrid macromolecular compound during blood storage.

Main Methods:

Rat blood was stored at 4±1°C with citrate-phosphate-glucose additive solution.
Blood viscosity was measured across a range of shear rates (3-300 sec⁻¹).
The impact of a hybrid macromolecular compound on viscosity was assessed.

Main Results:

Storage for three days at 4±1°C induced reproducible blood hyperviscosity.
Blood viscosity increased significantly within the first three days of storage.
The hybrid macromolecular compound effectively improved hemorheological properties, reducing viscosity.

Conclusions:

Rat blood storage under specified conditions provides a valid model for blood hyperviscosity.
This model is suitable for screening agents with hemorheological activity.
The tested compound demonstrates potential for mitigating storage-induced changes in blood viscosity.