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Updated: Mar 13, 2026

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung
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Allergic bronchopulmonary aspergillosis

T G Radha, R Viswanathan

    Respiration; International Review of Thoracic Diseases
    |January 1, 1978
    PubMed

    Insights

    Allergic bronchopulmonary aspergillosis (ABPA) is rare, but this study found the antibiotic Hamycin effective in treating 7 patients. Hamycin showed good initial results, alleviating symptoms and clearing Aspergillus fumigatus from sputum.

    Area of Science:

    • Medical Mycology
    • Pulmonology
    • Infectious Diseases

    Background:

    • Allergic bronchopulmonary aspergillosis (ABPA) is an uncommon condition.
    • Asthma sensitization to Aspergillus antigen is prevalent globally due to the fungus's widespread presence.
    • The Mycology Department diagnosed 46 ABPA cases over 14 years.

    Purpose of the Study:

    • To understand the disease evolution of Allergic bronchopulmonary aspergillosis.
    • To evaluate the efficacy of Hamycin in treating ABPA patients.

    Main Methods:

    • Follow-up study of 17 Allergic bronchopulmonary aspergillosis patients.
    • Diagnosis confirmed by Aspergillus fumigatus in sputum and positive skin reactions.
    • Treatment group of 7 patients received oral Hamycin for 10 days.

    Main Results:

    • Immediate positive outcomes observed in treated patients.
    • Marked alleviation of subjective symptoms reported.
    • Absence of Aspergillus fumigatus in sputum post-treatment.

    Conclusions:

    • Hamycin demonstrates promising immediate results for Allergic bronchopulmonary aspergillosis treatment.
    • The antibiotic Hamycin warrants further clinical trials for ABPA management.

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