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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
[Integrated Care Protocol: Hypertension]
Gabriela Borrayo-Sánchez1, Martin Rosas-Peralta2, María Cristina Guerrero-León3
1Instituto Mexicano del Seguro Social, Dirección de Prestaciones Médicas, Coordinación de innovación en Salud, Programa "A todo Corazón, Código Infarto". Ciudad de México, México.
Insights
Hypertension, a common cardiovascular risk factor, affects 30% of adults, often undiagnosed. The Mexican Institute of Social Security
Area of Science:
- Cardiology
- Public Health
- Internal Medicine
Background:
- Hypertension is a leading cardiovascular risk factor, causing severe complications like stroke, heart failure, and kidney failure.
- Approximately 30% of adults over 20 have hypertension, with 40% unaware due to asymptomatic onset.
- Treatment adherence and control remain suboptimal, with only half of diagnosed patients receiving treatment and half of those achieving target blood pressure (<14/90 mmHg).
Purpose of the Study:
- To introduce the Integrated Care Protocols (PAI) initiative by the Mexican Institute of Social Security for managing major diseases.
- To outline a multidisciplinary approach integrating three levels of medical care for hypertension management.
- To detail updated diagnostic and therapeutic strategies for hypertension, including special populations.
Main Methods:
- The protocol integrates care across primary, secondary, and tertiary levels.
- It emphasizes the roles of a multidisciplinary team: doctors, nurses, social workers, psychologists, and nutritionists.
- Includes updated guidelines on diagnostic criteria, blood pressure measurement (office and out-of-office), pharmacotherapy (mono-, dual-, triple-therapy), non-drug interventions, and follow-up.
Main Results:
- Presents an algorithmic approach for diagnosis and treatment of hypertension.
- Addresses the diagnostic workup for secondary hypertension.
- Covers specific management strategies for hypertension in pregnancy, hypertensive crises, elderly patients, and those with ischemic or nephropathic conditions.
Conclusions:
- The Integrated Care Protocols (PAI) offer a structured, multidisciplinary framework for improving hypertension management.
- Updated guidelines and algorithmic approaches aim to enhance diagnostic accuracy and therapeutic efficacy.
- This initiative seeks to improve hypertension control rates and mitigate associated cardiovascular complications.
Abstract:
Background: Hypertension is the most common cardiovascular risk factor that is responsible for complications such as cerebrovascular events, heart failure, acute myocardial infarction, kidney failure, arrhythmias and blindness. About 30% of the adult population older than 20 years is a carrier. 40% of carriers are unaware of suffering from it since its onset is generally asymptomatic. Unfortunately, of those who are already known to be hypertensive, only half take drug treatment and of these, only half achieve control figures (<14/90 mmHg). For several decades it has not been possible to forcefully modify the natural history of this disease despite the advancement of therapeutic drugs. The Mexican Institute of Social Security launches the initiative of the Integrated Care Protocols (PAI) of the main diseases. This protocol shows how the three levels of medical care are concatenated, the role of each of the members of the multidisciplinary team for medical care, including: doctor, nurse, social work, psychologist, nutritionist, among others and, to patient sharing. The main changes in diagnostic criteria, in-office and out-of-office blood pressure measurement, drug therapy (monotherapy, dual therapy and triple therapy) and non-drug therapy, and follow-up are presented. The diagnostic-therapeutic approach using algorithm as well as the diagnostic approach to secondary hypertension and special forms of hypertension such as in pregnancy, hypertensive crisis, hypertension in the elderly, ischemic or nephropathy patients.
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Critical attributes of NCIS include:

