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Mutagenic sterol hydroperoxides.

L L Smith, V B Smart, N Made Gowda

    Mutation Research
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Sterol hydroperoxides weakly mutagenize Salmonella typhimurium, with responses influenced by metabolism and phase separation. Superoxide and peroxide appear implicated in these mutagenic effects.

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    Area of Science:

    • Biochemistry
    • Toxicology
    • Genetics

    Background:

    • Sterol hydroperoxides are oxidation products of cholesterol.
    • Their potential mutagenicity requires investigation.

    Purpose of the Study:

    • To assess the direct mutagenicity of specific sterol hydroperoxides.
    • To elucidate the role of reactive oxygen species in their mutagenic activity.

    Main Methods:

    • A liquid medium incubation bioassay using Salmonella typhimurium strain TA 1537.
    • Testing the effects of added superoxide dismutase, rat liver S9 enzymes, and catalase.

    Main Results:

    • Weak, dose-response direct mutagenicity observed for two sterol hydroperoxides.
    • Metabolism and phase separation affected mutagenicity.

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  • Superoxide dismutase enhanced responses, while rat liver S9 and catalase diminished or abolished them.
  • Catalase also negated the effect of superoxide dismutase.

    • Conclusions:

    • Sterol hydroperoxides exhibit weak direct mutagenicity.
    • Superoxide and peroxide species are implicated in the observed mutagenic responses.
    • Enzymatic metabolism and detoxification pathways influence sterol hydroperoxide mutagenicity.