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Adequacy of blood pressure control in high-risk hypertensive patients: The DEGREE study

Victor J M Zeijen1, Melvin Lafeber2, Jorie Versmissen2

  • 1Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands.

International Journal of Cardiology
|February 17, 2022
PubMed

Insights

Blood pressure remains uncontrolled in many high-risk patients despite standard therapy. This highlights the need for new invasive treatments to manage hypertension effectively in these individuals.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Trials

Background:

  • Hypertension is a significant modifiable risk factor for cardiovascular events.
  • High-risk patients may benefit from novel invasive treatment options.
  • Assessing current treatment efficacy in high-risk populations is crucial.

Purpose of the Study:

  • To determine the prevalence of uncontrolled ambulatory blood pressure (ABP) in high-risk hypertensive patients on routine therapy.
  • To evaluate the proportion of patients not meeting guideline-recommended ABP targets.

Main Methods:

  • Single-center, cross-sectional study at Erasmus University Medical Center.
  • Inclusion of patients aged 18-80 years with hypertension and high cardiovascular risk.
  • Standardized office blood pressure (OBP) and 24-hour ABP measurements were performed.

Main Results:

  • 41.8% of patients did not meet ESC/ESH 24-h ABP targets; 52.7% did not meet OBP targets.
  • 59.3% did not meet ACC/AHA 24-h ABP targets; 79.1% did not meet OBP targets.
  • Patients were on a median of 2.0 Defined Daily Doses of antihypertensive drugs.

Conclusions:

  • A substantial proportion (40-60%) of high-risk hypertensive patients have uncontrolled blood pressure despite guideline-recommended therapy.
  • These findings underscore the need for research into novel invasive blood pressure-lowering treatments.
  • Current therapies may be insufficient for achieving optimal blood pressure control in this patient group.
Abstract

Keywords:
AmbulatoryAntihypertensive agentsBlood pressure monitoringCardiovascular diseasesGuidelineHypertensionPrevalence

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