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The roles of G3BP1 in human diseases (review)
Yidong Ge1, Jiabei Jin1, Jinyun Li1
1The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathphysiology, Medical School of Ningbo University, Ningbo 315211, China.
Abstract:
Ras-GTPase-activating protein binding protein 1 (G3BP1) is a multifunctional binding protein involved in a variety of biological functions, including cell proliferation, metastasis, apoptosis, differentiation and RNA metabolism. It has been revealed that G3BP1, as an antiviral factor, can interact with viral proteins and regulate the assembly of stress granules (SGs), which can inhibit viral replication. Furthermore, several viruses have the ability to hijack G3BP1 as a cofactor, recruiting translation initiation factors to promote viral proliferation. However, many functions of G3BP1 are associated with other diseases. In various cancers, G3BP1 is a cancer-promoting factor, which can promote the proliferation, invasion and metastasis of cancer cells. Moreover, compared with normal tissues, G3BP1 expression is higher in tumor tissues, indicating that it can be used as an indicator for cancer diagnosis. In this review, the structure of G3BP1 and the regulation of G3BP1 in multiple dimensions are described. In addition, the effects and potential mechanisms of G3BP1 on various carcinomas, viral infections, nervous system diseases and cardiovascular diseases are elucidated, which may provide a direction for clinical applications of G3BP1 in the future.
Insights
Ras-GTPase-activating protein binding protein 1 (G3BP1) is a key protein in cell functions and disease. This review explores G3BP1
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Ras-GTPase-activating protein binding protein 1 (G3BP1) is a multifunctional protein.
- G3BP1 plays roles in cell proliferation, metastasis, apoptosis, differentiation, and RNA metabolism.
- G3BP1 acts as an antiviral factor by regulating stress granules (SGs) and inhibiting viral replication.
Purpose of the Study:
- To review the structure and multi-dimensional regulation of G3BP1.
- To elucidate the effects and mechanisms of G3BP1 in various diseases.
- To explore the potential clinical applications of G3BP1.
Main Methods:
- Literature review of G3BP1 functions and disease associations.
- Analysis of G3BP1's role in viral infections.
- Investigation of G3BP1's involvement in cancer, nervous system, and cardiovascular diseases.
Main Results:
- G3BP1 is upregulated in tumors and promotes cancer cell proliferation, invasion, and metastasis.
- Viruses can hijack G3BP1 to promote their own replication.
- G3BP1's dysregulation is linked to various pathological conditions.
Conclusions:
- G3BP1 is a significant factor in diverse biological processes and diseases.
- G3BP1's elevated expression in cancer suggests diagnostic potential.
- Further research into G3BP1 mechanisms may lead to novel therapeutic strategies.
