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Making Security Viral: Shifting Engineering Biology Culture and Publishing.

Rebecca Mackelprang1, Katarzyna P Adamala2, Emily R Aurand1

  • 1Engineering Biology Research Consortium, 5885 Hollis Street, Emeryville, California 94608, United States.

ACS Synthetic Biology
|February 18, 2022
PubMed
Summary

Publishing protocols for synthesizing dangerous viruses like SARS-CoV-2 requires careful security reviews. Enhanced safety measures in synthetic biology research publications are crucial to prevent misuse and ensure responsible scientific advancement.

Keywords:
SARS-CoV-2biosafetybiosecurityengineering biologysynthetic biology

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Area of Science:

  • Synthetic Biology
  • Bioengineering
  • Virology

Background:

  • Engineering biology tools enable rapid gene and genome synthesis, crucial for developing diagnostics, therapeutics, and vaccines.
  • The COVID-19 pandemic highlighted the rapid application of these tools, emphasizing the importance of knowledge sharing.
  • Publications detailing the *de novo* synthesis of SARS-CoV-2, including protocols, raise significant biosecurity concerns.

Purpose of the Study:

  • To address the risks associated with publishing detailed protocols for the synthesis of dangerous pathogens.
  • To propose recommendations for enhancing the security of synthetic biology research publications.
  • To advocate for a robust publication framework that balances open science with biosafety.

Main Methods:

  • Review of existing publications on SARS-CoV-2 synthesis.
  • Analysis of potential risks associated with the open sharing of synthetic biology protocols.
  • Development of recommendations for safety and security reviews in scientific publishing.

Main Results:

  • The open publication of *de novo* synthesis protocols for highly transmissible pathogens presents security risks, especially for laboratories unfamiliar with handling such agents.
  • Current publication practices may not adequately address the biosecurity implications of engineering biology research.
  • There is a need for enhanced security considerations within the scientific publication process.

Conclusions:

  • Mandatory safety and security reviews for protocol manuscripts detailing the synthesis of certain pathogenic viruses are recommended.
  • Published papers should include transparency regarding security review discussions.
  • A governance framework for incorporating basic security screening into the publication process of engineering biology/synthetic biology manuscripts is essential for a secure research enterprise.