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[Lincosamides].

J C Pechère

    Pathologie-Biologie
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Clindamycin, a lincosamide antibiotic, effectively treats Gram-positive cocci and anaerobic infections by inhibiting protein synthesis. While generally well-tolerated, it carries a risk of pseudomembranous colitis, limiting its prophylactic use.

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    Area of Science:

    • Pharmacology and Microbiology
    • Antibiotic Mechanisms and Applications

    Context:

    • Lincosamides, including lincomycin and clindamycin, are a class of antibiotics.
    • Clindamycin is increasingly preferred due to higher activity.
    • These agents target Gram-positive cocci and anaerobic bacteria.

    Purpose:

    • To review the properties, efficacy, and limitations of lincosamide antibiotics, particularly clindamycin.
    • To highlight key pharmacokinetic and pharmacodynamic characteristics.
    • To outline clinical indications and contraindications.

    Summary:

    • Lincosamides bind to the 50S ribosomal subunit, inhibiting bacterial protein synthesis.
    • Clindamycin exhibits excellent oral absorption (90%) and a half-life of 2-3.8 hours, with reduced clearance in renal/hepatic impairment.

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  • Effective against anaerobes (e.g., Bacteroides fragilis) and Gram-positive cocci; poorly active against Gram-negative aerobes, often requiring combination therapy.

    • Impact:

    • Clindamycin is indicated for anaerobic infections (intestinal, vaginal) and specific aerobic infections.
    • Potential adverse effects include pseudomembranous colitis, contraindicating its prophylactic use in colorectal surgery.
    • Understanding lincosamide profiles guides appropriate clinical use and combination strategies.