Associations Between GGT/HDL and MAFLD: A Cross-Sectional Study.

Area of Science:

• Metabolic Syndrome Research
• Hepatology
• Diabetes Mellitus Research

Background:

• Metabolic associated fatty liver disease (MAFLD) is a growing concern in patients with type 2 diabetes (T2DM).
• Identifying reliable biomarkers for MAFLD risk stratification is crucial for early intervention.
• The interplay between metabolic factors and liver health in T2DM requires further investigation.

Purpose of the Study:

• To examine the association between the GGT/HDL ratio, TYG-BMI, and MAFLD in a Chinese T2DM population.
• To determine the role of TYG-BMI in mediating the relationship between GGT/HDL and MAFLD.

Main Methods:

• Cross-sectional analysis of 1434 hospitalized T2DM patients.
• Spearman correlation and multiple logistic regression analyses were employed.
• Mediation analysis assessed the role of TYG-BMI in the GGT/HDL-MAFLD association.

Main Results:

• Higher GGT/HDL levels were observed in patients with MAFLD.
• Elevated GGT/HDL was an independent risk factor for MAFLD in T2DM patients.
• GGT/HDL independently predicted MAFLD specifically in T2DM patients with BMI > 23 kg/m2.

Conclusions:

• The GGT/HDL ratio is positively associated with MAFLD incidence in T2DM patients with BMI > 23 kg/m2.
• TYG-BMI partially mediates the association between GGT/HDL and MAFLD.
• GGT/HDL may serve as a potential biomarker for MAFLD risk in specific T2DM subgroups.