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Kidney-Related Outcome in Cardiorenal Syndrome Type 3
Kim Drubel1, Benedikt Marahrens1, Oliver Ritter1
1Klinik für Kardiologie und Nephrologie, University Hospital Brandenburg, Medical School of Brandenburg, Brandenburg, Hochstraße 29, 14770 Brandenburg, Germany.
Insights
Cardiorenal syndrome type 3 is a serious condition with high mortality and dialysis rates. Patients with cardiac complications require urgent nephrologist attention for better outcomes.
Area of Science:
- Nephrology
- Cardiology
- Critical Care Medicine
Background:
- Cardiorenal syndrome (CRS) type 3, characterized by acute kidney injury (AKI) due to cardiac dysfunction, poses a significant clinical challenge.
- Understanding the outcomes of CRS type 3 is crucial for optimizing patient management and improving survival rates.
Purpose of the Study:
- To evaluate the in-hospital mortality, dialysis requirements, and kidney function recovery in patients diagnosed with CRS type 3.
- To identify the high-risk patient population requiring specialized nephrological care.
Main Methods:
- A retrospective, observational study was conducted at a single center.
- Data from 95 patients diagnosed with CRS type 3 between January and December 2019 were analyzed.
- Study endpoints included in-hospital death, need for dialysis, and kidney function recovery.
Main Results:
- A total of 1,334 AKI alerts were screened, with 95 patients meeting CRS type 3 criteria.
- High mortality rates were observed: 47.1% in females and 43.6% in males.
- Dialysis was required in 46.8% of females and 33.3% of males. Complete kidney function recovery occurred in only 35.8% of patients.
Conclusions:
- The study highlights notably high rates of mortality, dialysis dependence, and lack of kidney function recovery in CRS type 3 patients.
- Patients with AKI and cardiac complications necessitate immediate and focused attention from nephrologists.
- Prompt intervention and specialized care are critical for improving outcomes in this vulnerable patient group.
Methods:
A single-center, retrospective and observational trial. All subjects with positive AKI alert, treated at the University Hospital Brandenburg between January and December 2019, were evaluated. Definition of CRS type 3 was according to predefined criteria. The three endpoint categories were in-hospital death, dialysis, and recovery of kidney function.
Results:
. A total number of 1,334 AKI alerts were screened. Finally, 95 subjects received the diagnosis CRS type 3. The survival rates were 47.1% (females) and 43.6% (males). 46.8% of affected females and 33.3% of the males required dialysis therapy. Complete recovery at the time of discharge occurred in 35.8%, and no recovery at all was found in 54.7%.
Conclusions:
. All three predefined study endpoints, the mortality, the prevalence of dialysis, and the percentage of subjects without recovery of kidney function, were notably high. Therefore, AKI patients with imminent or established cardiac complications require the highest attention of nephrologists in charge.
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