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A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
Published on: February 2, 2024
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Dynamic risk profiling of HCC recurrence after curative intent liver resection
Tommy Ivanics1,2,3, Carla Fiorella Murillo Perez1,4, Marco P A W Claasen1,5
1Multi-Organ Transplant Program, University Health Network Toronto, Toronto, Ontario, Canada.
Hepatology (Baltimore, Md.)
|February 18, 2022
Summary
Multistate modeling offers realistic prognostication for liver cancer patients after resection, predicting disease progression and survival. An online calculator aids in managing surveillance and therapy for better patient outcomes.
Area of Science:
- Hepatobiliary surgery
- Oncology
- Biostatistics
Background:
- Outcomes after liver resection for hepatocellular carcinoma (HCC) are dynamic, with possibilities of multiple recurrences and metastases.
- Accurate prognostication is crucial for guiding patient management and surveillance strategies.
Purpose of the Study:
- To evaluate the natural progression, pattern, and timing of disease states after liver resection for HCC.
- To develop a practical calculator for prognostic information using multistate modeling.
Main Methods:
- Retrospective analysis of 486 adult patients undergoing liver resection for HCC (2000-2018).
- Multistate analysis modeled transitions between states: surgery, intrahepatic recurrence, distant metastasis, and death.
- Development of an online multistate model calculator.
Main Results:
- Within 60 months post-liver resection, 33.1% remained disease-free, 31.0% had intrahepatic recurrence, 16.3% developed distant metastasis, and 19.8% died.
- Transition probability to first intrahepatic recurrence increased over time, influenced by tumor size, satellite lesions, and microvascular invasion.
- An online calculator is available at https://multistatehcc.shinyapps.io/home/.
Conclusions:
- Multistate modeling provides more realistic prognostication than standard methods by accounting for various postoperative disease states and transitions.
- The developed calculator offers meaningful data to guide postoperative surveillance and therapy decisions for HCC patients.
