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[Metabonomics and its application in Chinese medicine processing].

Xin-Tong Wei¹, Jie Wang², Wei Chen³

¹School of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250355, China School of Pharmacy, Naval Medical University Shanghai 200433, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|February 18, 2022

Summary

Metabonomics, a novel omics technology, offers a holistic approach to understanding traditional Chinese medicine (TCM) processing. This study explores its application in elucidating TCM processing mechanisms and ensuring quality control for modernization and internationalization.

Keywords:

Chinese medicine processing metabonomics processing mechanism quality control

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Area of Science:

Integrative and Complementary Medicine
Metabolomics
Pharmacognosy

Background:

Traditional Chinese Medicine (TCM) processing is crucial for medicinal material efficacy but faces challenges in modernization and internationalization.
Inheritance and development of TCM processing require innovative approaches to address current limitations.

Purpose of the Study:

To summarize the application of metabonomics in understanding Chinese medicine processing mechanisms.
To review the use of metabonomics for quality control in TCM processing.
To explore future prospects of metabonomics in the field of Chinese medicine processing.

Main Methods:

Utilizing metabonomics, an omics technology employing techniques like Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectrometry (LC-MS).
Investigating changes in endogenous small molecule metabolic networks in response to external stimuli.
Applying a holistic, dynamic, and comprehensive analytical approach consistent with TCM principles.

Main Results:

Metabonomics has been increasingly applied to study the processing mechanisms of Chinese medicine.
The technology provides valuable insights into quality control aspects of TCM processing.
The holistic and dynamic nature of metabonomics aligns well with TCM's philosophical underpinnings.

Conclusions:

Metabonomics is a powerful tool for advancing the scientific understanding and modernization of Chinese medicine processing.
Its application facilitates quality control and supports the internationalization of TCM.
Future research should further leverage metabonomics to unlock the full potential of TCM processing.