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Updated: Oct 3, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
[Diterpenoids from Rabdosia flexicaulis]
Xu Liu1, Chun-Xia Chen2, Ji-Zhou Wu3
1Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430040, China School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430040, China.
Abstract:
The genus Rabdosia is famous for the abundance of diverse and novel ent-kaurane diterpenoids. However, only a few ent-kauranoids have been discovered from R. flexicaulis since the investigation on its chemical constituents is not systematic. To find novel bioactive diterpenoids, the ethyl acetate extract of the above ground part of R. flexicaulis in Daofu County, Sichuan Province was obtained by column chromatography. One new compound and five known ones were identified as flexicaulin E(1), forrestin B(2), inf-lexarabdonin D(3), 7α-hydroxydehydroabietic acid(4), 15-hydroxydehydroabietic acid(5), and pomiferin F(6) by spectral techniques. Compounds 1-3 were the ent-kaurane diterpenoids isolated from this species for the first time. Compounds 4-6, aromatic abie-tanoids, were isolated from the genus Rabdosia for the first time.
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