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Microfluidic-based in vitro thrombosis model for studying microplastics toxicity.

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Area of Science:

  • Toxicology
  • Biomedical Engineering
  • Vascular Biology

Background:

  • Microplastic (MP) health impacts are a growing concern.
  • A realistic toxicology platform is needed to study MP-related vascular issues.
  • Existing methods lack the ability to dynamically assess MP interactions within the vascular system.

Purpose of the Study:

  • To develop and validate an optically assisted thrombus platform for studying microplastic interactions with the vascular system.
  • To evaluate the accumulation risk of microplastics in a mouse model.
  • To investigate the effects of microplastics on thrombus formation and stability.

Main Methods:

  • An endothelialized microfluidic chip was used to induce and visualize thrombosis via optical irradiation.
  • Whole blood containing microplastics was perfused through the chip to observe MP invasion.
  • A mouse model was employed to assess microplastic accumulation in vivo.
  • In vitro experiments validated the effects of microplastics on thrombus properties.

Main Results:

  • A mouse model demonstrated cumulative microplastic risk in blood with continuous exposure (P < 0.0001).
  • On-chip experiments revealed that microplastic invasion significantly decreased fibrin-platelet binding (P < 0.0001).
  • Microplastic exposure increased the risk of thrombus shedding in real blood flow compared to normal thrombi.

Conclusions:

  • The optically assisted thrombus platform provides a novel method for investigating microplastic-vascular interactions.
  • Microplastics can accumulate in the bloodstream and compromise thrombus stability.
  • This research highlights potential health risks associated with microplastic exposure and offers a tool for further toxicological studies.