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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
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Implications of structural right ventricular involvement in patients with hypertrophic cardiomyopathy

Yu Zhang1, Yuming Zhu1, Mo Zhang2

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongdan Santiao No. 9, 100006 Beijing, China.

European Heart Journal. Quality of Care & Clinical Outcomes
|February 18, 2022
PubMed

Insights

Right ventricular involvement in hypertrophic cardiomyopathy (HCM) predicts worse outcomes, including cardiovascular death. Genetic factors are also linked to RV involvement in HCM patients.

Area of Science:

  • Cardiology
  • Genetics
  • Clinical Medicine

Background:

  • Right ventricular (RV) involvement in hypertrophic cardiomyopathy (HCM) is understudied.
  • Understanding RV manifestations is crucial for risk stratification in HCM.

Purpose of the Study:

  • To evaluate the risk prediction value of RV involvement in HCM.
  • To investigate the genetic characteristics associated with RV involvement in HCM patients.

Main Methods:

  • 893 HCM patients were assessed for RV hypertrophy, obstruction, or late gadolinium enhancement.
  • Survival analyses evaluated cardiovascular death, all-cause death, and heart failure (HF)-related death.
  • Genetic testing was performed on 669 patients to identify genetic variants.

Main Results:

  • RV involvement was identified in 12.8% of patients and was an independent risk factor for adverse cardiovascular outcomes.
  • Patients with RV involvement showed a higher frequency of genotype-positive results and MYBPC3 variants.
  • Logistic analyses confirmed an independent correlation between RV involvement and genetic factors.

Conclusions:

  • RV involvement is a significant independent risk factor for mortality in HCM patients.
  • Genetic factors likely play a role in the development of RV involvement in HCM.
Abstract

Keywords:
Genetic testingHypertrophic cardiomyopathyRight ventricleRisk prediction

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