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Design of Bifunctional Amino Tf-Amide Organocatalysts and Application in Various Asymmetric Transformations
Hyo-Jun Lee1, Keiji Maruoka2,3
1Department of Chemistry, Kunsan National University, Gunsan, 54150, Republic of Korea.
Abstract:
In this personal account, we describe our recent developments on the four types of amino Tf-amide catalysts in asymmetric transformations. Firstly, axially chiral biaryl-based secondary-amino Tf-amide catalyzed various stereoselective reactions via enamine intermediates. Secondly, pyrrolidine-based secondary-amino aliphatic Tf-amide catalyzed asymmetric direct Mannich reaction. Thirdly, chiral primary-amino aliphatic Tf-amide catalyzed asymmetric direct aldol reaction and conjugate addition. Finally, modified chiral amino aromatic Tf-amide catalyzed asymmetric transformations. These four different strategies are illustrated by using various organocatalyzed asymmetric transformations.
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