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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

945
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

870
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Oct 3, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Structural-Functional Glaucoma Progression Trajectory in 2-Dimensional Space.

Agustina de Gainza1,2, Esteban Morales1,2, Diana Salazar1,2

  • 1Glaucoma Division, Jules Stein Eye Institute.

Journal of Glaucoma
|February 18, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a novel method for visualizing glaucoma progression using a 2D structural and functional (S/F) space. This approach offers clinicians a rapid and intuitive summary of patient glaucoma trajectories.

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Related Experiment Videos

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma is a progressive optic neuropathy characterized by structural damage and functional vision loss.
  • Accurate monitoring of glaucoma progression is crucial for timely intervention and management.
  • Current methods for visualizing glaucomatous change can be complex and time-consuming.

Purpose of the Study:

  • To develop and present a method for visualizing glaucomatous change in a two-dimensional (2D) structural and functional (S/F) space.
  • To provide a rapid and intuitive summary of glaucoma progression for clinical use.

Main Methods:

  • A retrospective longitudinal observational study was conducted.
  • A structural score was developed using data from normal and glaucomatous eyes (Group I).
  • Longitudinal data from glaucomatous eyes (Group II) were analyzed using vector analysis in a 2D S/F space, plotting optical coherence tomography scores against visual field index.

Main Results:

  • The study analyzed 957 vectors from 582 patients with open-angle glaucoma over a mean follow-up of 6.9 years.
  • Mean baseline mean deviation varied across disease severity groups, from -0.8 dB (preperimetric) to -11.2 dB (severe).
  • Mean vector slopes indicated increasing rates of structural-functional progression with disease severity, ranging from 0.88 to 2.69.

Conclusions:

  • The developed method enables rapid visualization of glaucoma progression in a 2D S/F space.
  • This approach effectively integrates extensive longitudinal data into an intuitive summary.
  • The visualization tool aids clinicians in understanding and managing patient glaucoma trajectories.