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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
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Forging Forward in Photodynamic Therapy.

Gwendolyn M Cramer, Keith A Cengel, Theresa M Busch

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    Photodynamic therapy (PDT) uses light-activated drugs to treat various cancers. Early research established PDT

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    Area of Science:

    • Oncology
    • Photomedicine

    Background:

    • Photodynamic therapy (PDT) utilizes photosensitizers activated by light to target diseased tissues.
    • The 1978 study by Dougherty et al. was a foundational clinical trial for PDT in treating malignancies.

    Observation:

    • The landmark 1978 study evaluated photosensitizer dose, drug-light interval, and fractionation for efficacy and safety.
    • Early evidence for PDT's antitumor mechanisms, including cell death, antivascular, and immune effects, emerged from this research.

    Findings:

    • PDT's multifaceted mechanisms involve various cell death pathways and immune stimulation.
    • Mechanism-informed PDT protocols enhance its role in multimodality cancer treatment.

    Implications:

    • Understanding PDT mechanisms guides its application beyond oncology.
    • Continued research into cell death and immune responses will refine future PDT protocols and applications.