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[Penicillamine in 1985].

J P Camus, A C Koeger, C Laveant

    Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    D-penicillamine shows limited long-term efficacy for rheumatoid arthritis due to frequent side effects and treatment failures. While initial results can be promising, sustained therapeutic benefits are often not achieved.

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    The Journal of rheumatology·1999

    Area of Science:

    • Rheumatology
    • Pharmacology
    • Immunology

    Context:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
    • D-penicillamine has been used historically in RA management.
    • Understanding long-term treatment outcomes is crucial for RA patients.

    Purpose:

    • To review the historical discovery and application of D-penicillamine in rheumatoid arthritis.
    • To define practical management strategies for D-penicillamine treatment in RA.
    • To evaluate the overall therapeutic efficacy and limitations of D-penicillamine in RA.

    Summary:

    • D-penicillamine's therapeutic utility in rheumatoid arthritis is constrained by a high incidence of adverse effects.
    • Treatment outcomes are often suboptimal due to frequent "therapeutic escapes" or lack of sustained response.

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  • Despite initial positive responses observed in the early years of treatment, long-term effectiveness is limited.

    • Impact:

    • This review provides insights into the challenges of using D-penicillamine for rheumatoid arthritis.
    • It highlights the need for careful patient monitoring and alternative treatment strategies.
    • The findings contribute to optimizing the management of rheumatoid arthritis patients.