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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
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Enuresis and Hyperfiltration in Children With Sickle Cell Disease
Rima S Zahr1, Juan Ding2, Guolian Kang2
1Division of Pediatric Nephrology and Hypertension.
Journal of Pediatric Hematology/Oncology
|February 18, 2022
Summary
Nocturnal enuresis (bedwetting) is common in children with sickle cell disease (SCD). Early kidney hyperfiltration did not predict bedwetting, but severe SCD genotypes and male sex did. Non-renal factors may be important. Keywords: sickle cell disease, nocturnal enuresis, bedwetting, hyperfiltration, risk factors
Area of Science:
- Pediatric Nephrology
- Hematology
- Urology
Background:
- Nocturnal enuresis is a frequent symptom in pediatric patients with sickle cell disease (SCD).
- The risk factors contributing to the development of enuresis in children with SCD remain largely unknown.
- Glomerular hyperfiltration is an early indicator of kidney damage associated with SCD.
Purpose of the Study:
- This study investigated the hypothesis that glomerular hyperfiltration in early childhood is associated with a higher likelihood of nocturnal enuresis in pediatric patients with SCD.
- To identify potential risk factors for nocturnal enuresis in children with sickle cell disease.
Main Methods:
- A retrospective evaluation of children with SCD from the Evaluation of Nocturnal Enuresis and Barriers to Treatment among Pediatric Patients with SCD study.
- Prospective identification of children with nocturnal enuresis from the Sickle Cell Clinical Research and Intervention Program longitudinal cohort.
- Assessment of the relationship between early-life hyperfiltration (ages 3-5) and later development of enuresis.
Main Results:
- Nocturnal enuresis was reported in 46.5% of participants with SCD.
- Enuresis was more prevalent in individuals with HbSS/HbSβ 0 thalassemia and in male participants.
- Hyperfiltration from ages 3 to 5 was not associated with the subsequent development of enuresis. Severe SCD genotypes and male sex were associated with enuresis after age 5.
Conclusions:
- Glomerular hyperfiltration in early childhood is not a predictor of nocturnal enuresis in pediatric patients with sickle cell disease.
- Severe SCD genotypes and male sex are associated with nocturnal enuresis in children over age 5.
- Future research should explore non-renal risk factors to better predict the development of enuresis in this population.
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