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Diabetes, heart damage, and angiotensin II. What is the relationship link between them? A minireview

Adriana Pedreanez1, Jesus Mosquera2, Nelson Munoz3

  • 1Catedra de Inmunologia, Escuela de Bioanalisis, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.

Endocrine Regulations
|February 18, 2022
PubMed

Insights

Diabetic patients face high cardiovascular risks due to cardiac damage. This review explores how angiotensin II (Ang II), a key part of the renin-angiotensin system (RAS), contributes to this damage through inflammation.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Endocrinology

Background:

  • Cardiovascular complications are a leading cause of death in diabetic patients.
  • Diabetic patients exhibit significant changes in myocardial structure and function.
  • Angiotensin II (Ang II), a product of the renin-angiotensin system (RAS), is implicated in cardiac damage.

Purpose of the Study:

  • To review the role of Ang II in biochemical pathways contributing to cardiovascular damage in diabetes.
  • To understand the relationship between the renin-angiotensin system and diabetic cardiomyopathy.

Main Methods:

  • Exhaustive literature review of major databases.
  • Keywords used: angiotensin II, cardiovascular damage, renin angiotensin system, inflammation, diabetes mellitus.

Main Results:

  • The renin-angiotensin system (RAS) plays a critical role in cardiovascular regulation.
  • Recent research highlights the function of RAS and its link to diabetic cardiomyopathy.
  • Ang II acts as a proinflammatory peptide contributing to cardiac damage.

Conclusions:

  • Angiotensin II is a key mediator in the development of cardiovascular damage in diabetes.
  • Understanding the molecular mechanisms involving Ang II is crucial for managing diabetic cardiomyopathy.
  • The renin-angiotensin system's role extends beyond blood pressure control to include inflammatory pathways in diabetic hearts.
Keywords:
Angiotensin IIcardiovascular diseasediabetesrenin-angiotensin system

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