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Updated: Oct 3, 2025

Dissection of Hippocampal Dentate Gyrus from Adult Mouse
Published on: November 17, 2009
Highlights regarding prolactin in the dentate gyrus and hippocampus
Marta Carretero-Hernández1, Leonardo Catalano-Iniesta1, Enrique J Blanco1
1Department of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, Spain; Laboratory of Neuroendocrinology, Institute of Neurosciences of Castilla y León (INCyL), and Laboratory of Neuroendocrinology and Obesity, Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Spain.
Abstract:
Prolactin (PRL) is a pituitary hormone that has been typically related to lactogenesis in mammals. However, it has been described over 300 roles in the organism of vertebrae and its relationship with the central nervous system (CNS) is yet to be clarified. Mainly secreted by the pituitary gland, the source of prolactin in the CNS remains unclear, where some experiments suggest active transport via an unknown carrier or, on the contrary, PRL being synthesized on the brain. So far, it seems to be involved with neurogenesis, neuroprotection, maternal behavior and cognitive processes in the hippocampus and dentate gyrus, among other regions.
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