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Related Experiment Video

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Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

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Published on: July 10, 2016

Engineering tissue morphogenesis: taking it up a Notch.

Laura A Tiemeijer¹, Sami Sanlidag², Carlijn V C Bouten³

¹Faculty for Science and Engineering, Biosciences, Åbo Akademi University, Turku, Finland; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands; InFLAMES Research Flagship Center, Åbo Akademi University, Turku, Finland.

Trends in Biotechnology

|February 19, 2022

Summary

This summary is machine-generated.

Bioengineering functional tissues relies on controlling cell fate. The Notch signaling pathway offers precise regulation for tissue patterning and morphogenesis, enabling the creation of complex, functional tissues.

Keywords:

Notch signaling Notch signaling modulation ligand immobilization morphogenesis tissue patterning

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Area of Science:

Biomedical Engineering
Developmental Biology
Cell Signaling

Background:

Tissue bioengineering demands precise control over cell fate decisions.
The Notch signaling pathway is a juxtacrine signaling system crucial for regulating cell fate and tissue organization.
Its inherent characteristics make it amenable to engineering applications in tissue development.

Purpose of the Study:

To explore the physiological significance and mechanisms of Notch signaling.
To emphasize the potential of Notch signaling in engineering complex tissues.
To review current Notch activation methods and discuss future opportunities and challenges in its modulation for tissue engineering.

Main Methods:

Review of existing literature on Notch signaling.
Analysis of Notch pathway mechanisms and physiological roles.
Discussion of current Notch activation strategies and their engineering applications.

Main Results:

Notch signaling precisely controls cell fate and tissue organization.
The pathway's characteristics offer valuable tools for tissue patterning and morphogenesis.
Current methods for Notch activation are highlighted, alongside potential design strategies.

Conclusions:

Finely tuned control of Notch signaling is essential for generating tissues with accurate form and function.
Modulating Notch offers significant opportunities for advancing tissue engineering.
Challenges remain in optimizing Notch pathway control for complex tissue generation.