Related Experiment Video
Updated: Oct 3, 2025
In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase
Published on: April 4, 2025
Sex under pressure: stress facilitates Leishmania in vitro hybridization
Rubens L Monte-Neto1, Christopher Fernandez-Prada2, Nilmar S Moretti3
1Biotecnologia Aplicada ao Estudo de Patógenos (BAP) - Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brasil.
Abstract:
The selection of Leishmania hybrids in axenic culture was considered rare until recently, when Louradour and Ferreira et al., demonstrated that induced DNA damage facilitates genetic exchange, resulting in full genome tetraploid progenies in vitro. Meiosis-related gene homologues HAP2, GEX1, and RAD51 were found to be involved, opening new avenues for functional genomic studies.
