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Updated: Oct 3, 2025
08:34
Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns
Published on: September 16, 2019
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Disordered breathing in severe cerebral illness - Towards a conceptual framework.
Oliver Summ1, Nahid Hassanpour2, Christian Mathys3
1Faculty of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; Department of Neurological Intensive Care and Rehabilitation, Evangelisches Krankenhaus Oldenburg, Oldenburg, Germany.
Respiratory Physiology & Neurobiology
|February 19, 2022
Summary
Severe cerebral illness can cause various breathing disorders, including central hypoventilation. Further research is needed for diagnosis and treatment strategies for these critical neurological patients.
Area of Science:
- Neurology
- Pulmonology
- Critical Care Medicine
Background:
- Patients with severe cerebral illness often experience life-threatening breathing disturbances.
- Current diagnostic and therapeutic guidelines for these respiratory issues are lacking.
Purpose of the Study:
- To identify and classify breathing disorders in severe cerebral illness.
- To guide future research in pathophysiology, diagnosis, and treatment.
Main Methods:
- Analysis of polygraphy, transcutaneous capnometry, blood gas analysis, and radiological imaging.
- Inclusion of 15 patients from a neurological intensive care unit with severe cerebral illness and disordered breathing.
Main Results:
- Observed breathing disorders included acquired central hypoventilation syndrome (ACHS), central bradypnea/tachypnea, various apneas/hypopneas, Cheyne Stokes respiration, ataxic breathing, cluster breathing, and respiration alternans.
- Two patterns, abrupt breathing pattern switches and respiration alternans, suggest a rhythmogenic respiratory network.
Conclusions:
- Severe cerebral illness can lead to ACHS and diverse respiratory rhythm disorders.
- Polygraphy, capnometry, blood gas analysis, and MRI show promise for diagnosis and research.
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