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Published on: January 28, 2019
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A shift in circulating rotaviral genotypes among hospitalized neonates
Sudhabharathi Reju1, Padma Srikanth2, Sribal Selvarajan1
1Department of Microbiology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Scientific Reports
|February 19, 2022
Summary
Rotavirus (RV) infection affects 34% of hospitalized neonates, with higher rates in intensive care units and those with gastrointestinal issues. Emerging G12P[11] strains are noted, highlighting the need for RV surveillance.
Area of Science:
- Neonatal infectious diseases
- Virology
- Public health
Background:
- Nosocomial rotavirus (RV) infections pose significant challenges in neonatal care due to prolonged shedding and environmental contamination.
- Asymptomatic RV infections in neonates are understudied, yet crucial for understanding transmission dynamics.
Purpose of the Study:
- To screen hospitalized neonates for rotavirus infection.
- To analyze clinical manifestations associated with RV acquisition.
- To identify prevalent RV genotypes and risk factors in a tertiary care setting.
Main Methods:
- Stool samples from 523 neonates hospitalized for over 48 hours were collected.
- Rotavirus antigen screening was performed using ELISA, with positive samples confirmed by semi-nested RT-PCR.
- Genotyping of detected rotavirus strains was conducted.
Main Results:
- Rotavirus was detected in 34% of neonates.
- Genotypes G12P[11] (44.4%) and G10P[11] (42.6%) were predominant.
- Higher RV shedding was associated with ICU admissions (p < 0.05), and higher acquisition risk with low-cost facility ICU stays (p < 0.05).
- RV rates were higher (36.9%) in neonates with gastrointestinal manifestations.
Conclusions:
- Neonatal rotavirus infection is prevalent, particularly in ICUs and among those with gastrointestinal issues.
- The emergence of G12P[11] alongside established G10P[11] indicates evolving rotavirus epidemiology.
- Continuous RV surveillance is essential for managing emerging strains and improving infection control strategies.
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