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The NAFLD-MAFLD debate: Is there a Consensus-on-Consensus methodology?

Yasser Fouad1, Jean-François Dufour2,3, Ming-Hua Zheng4,5,6

  • 1Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, Minia, Egypt.

Liver International : Official Journal of the International Association for the Study of the Liver
|February 19, 2022
PubMed
Summary
This summary is machine-generated.

The term metabolic (dysfunction) associated fatty liver disease (MAFLD) is superior for clinical practice. Evidence shows consensus has been reached, urging focus on patient care.

Keywords:
MAFLDconsensus, Delphi

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Area of Science:

  • Hepatology
  • Metabolic Disorders
  • Liver Disease Classification

Background:

  • Controversy exists regarding the naming and redefinition of fatty liver disease linked to metabolic dysfunction.
  • The term metabolic (dysfunction) associated fatty liver disease (MAFLD) is proposed as a superior definition for clinical and academic use.
  • Arguments against the name change often cite a lack of consensus.

Purpose of the Study:

  • To discuss the meaning and methods of achieving scientific consensus in the context of fatty liver disease nomenclature.
  • To present evidence supporting the consensus on changing the name from non-alcoholic fatty liver disease (NAFLD) to MAFLD.
  • To advocate for redirecting focus towards patient care and capitalizing on the ongoing debate.

Main Methods:

  • Review of arguments surrounding the nomenclature debate in fatty liver disease.
  • Analysis of scientific consensus models and their application to the NAFLD/MAFLD discussion.
  • Presentation of evidence supporting the achievement of consensus for MAFLD.

Main Results:

  • Scientific consensus on the utility and adoption of the MAFLD definition has been achieved.
  • The discourse on consensus methods is crucial for advancing the field.
  • The debate has generated momentum that can be leveraged for patient benefit.

Conclusions:

  • Consensus supports the adoption of the MAFLD definition over NAFLD.
  • Further discussion on scientific consensus is vital for the hepatology field.
  • Stakeholders should focus energy on improving patient outcomes for metabolic (dysfunction) associated fatty liver disease.