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Updated: Oct 3, 2025

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LncRNA-miRNA-mRNA regulatory axes in endometrial cancer: a comprehensive overview

Abhishek Shetty1, Thejaswini Venkatesh2, Shama Prasada Kabbekodu3

  • 1Department of Biosciences, Mangalore University, Mangalagangothri, Mangalore, 574 199, Karnataka, India.

Archives of Gynecology and Obstetrics
|February 19, 2022
PubMed
Abstract

Insights

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with messenger RNAs (mRNAs) to regulate endometrial cancer (EC). Dysregulated lncRNA-miRNA-mRNA networks offer new diagnostic and therapeutic targets for EC.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Endometrial cancer (EC) is a common gynecological malignancy with unclear etiology and prognostic factors.
  • Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play crucial roles in tumorigenesis and disease progression.
  • Dysregulation of lncRNA-miRNA-mRNA interactions is increasingly recognized in the pathophysiology of EC.

Purpose of the Study:

  • To review the role of lncRNA-miRNA-mRNA axes in endometrial cancer.
  • To elucidate the molecular mechanisms underlying endometrial carcinogenesis.
  • To identify potential diagnostic biomarkers and therapeutic targets for EC.

Main Methods:

  • A comprehensive literature review was performed.
  • Focused on studies investigating lncRNA-miRNA-mRNA interactions in EC.
  • Synthesized findings on the regulatory roles of these interactions.

Main Results:

  • lncRNAs function as molecular sponges, sequestering tumor suppressor miRNAs.
  • This sequestration disrupts miRNA function, leading to dysregulation of target mRNAs.
  • These molecular events contribute to the regulation and progression of EC.

Conclusions:

  • lncRNA-miRNA-mRNA networks are integral to endometrial carcinogenesis.
  • Understanding these pathways enhances conceptualization of EC's molecular basis.
  • These interactions present promising avenues for novel diagnostic biomarkers and therapeutic interventions in EC.
Keywords:
Endometrial cancerLong non-coding RNAMALAT1miRNA

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